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What is the Replication Crisis?

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The finding became a fixture of the replication crisis after three independent teams failed to reproduce it.

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Overview

The replication crisis is the discovery that a large share of published studies do not give the same result when other researchers run them again. That second run is a replication: the same method, new participants, another team. Any single study can land on a fluke, so one run is never proof. How many flukes reach print depends on how a field works. Small samples, analysis chosen after seeing the data, and journals that publish the surprising positives and not the dull nulls all let more through than chance alone would. In 2015 a team of psychologists reran 100 published studies from their own field. The originals had been statistically significant 97 times out of 100. The reruns were significant 36 times, and the effects they found were about half the size. A failed rerun does not show the first result was false. It shows one run was weak evidence. So the question for any "a study finds" headline is whether anyone has found it twice.
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Overview

The replication crisis is science finding out that a worrying chunk of its published results don't turn up again when somebody else runs the same study. That second go is a replication: same method, fresh people, another lab. One study can always get lucky, so a solo run proves nothing on its own. The trouble is how many lucky runs were getting printed. Tiny studies that wobble, number-crunching chosen after a peek at the data, and journals that only want the jaw-dropper results stacked the shelves with flukes. In 2015 psychologists reran 100 of their own field's published studies. Round one, 97 had cleared the bar for "statistically significant". Round two, 36 did, and the effects came out about half as big. That's not 64 scandals. It's 64 reminders that one run is one run. Next time a headline says "a study finds", ask the one thing that matters: has it been found twice? 😎

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Detail

The replication crisis is the finding, made when researchers began redoing published studies in bulk, that many do not hold up. A replication is a second, independent run: another team follows the original method with new participants and sees whether the result returns. For decades this was rare. Journals wanted new findings rather than repeats, and careers were built on discoveries, so the check that research relies on was seldom carried out. Any single study can hit a fluke, so one run is never proof. How many flukes reach print depends on three habits. A small sample swings by chance, so a small study is wrong more often. Choosing how to analyse the data after seeing it lets luck pick the method, which is p-hacking. And journals print the surprising positives while studies that found nothing stay unpublished, which is publication bias. In 2011 a group of 270 researchers began the largest such check. They reran 100 studies published in three psychology journals in 2008, finished in 2014 and reported in 2015. Of the originals, 97 had been statistically significant. Of the reruns, 36 were, and the effects measured were about half the size of the originals. Which results held up was predicted by the strength of the first result, not by who ran the rerun, and the most surprising findings held up least. The authors added a caution: a failed rerun does not mean the original was a false positive, because a second run can fail by chance or because a detail of the method mattered. It means one study is weak evidence. The fixes since: write the analysis down before collecting data (preregistration), recruit more participants, let journals accept a study on its design before any results are in, and share the data. For a reader, the test of any finding is whether someone else has got it again.
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Detail

The replication crisis is the moment science checked its own homework and a lot of it didn't add up. A replication is the retry: a fresh lab reruns a published experiment on fresh people and watches whether the result reappears. Here's the scoreboard that gave the thing its name. From 2011 to 2014, 270 researchers redid 100 experiments from three psychology journals' 2008 issues, and in 2015 they handed in the results. The originals had cleared the bar for statistically significant 97 times. The redos cleared it 36 times, and the effects shrank to roughly half. One in three came back. Why so few? One run can always fluke, careful or not, so a lone result was no proof to begin with. The deeper problem was how many flukes were getting in. Tiny studies wobble, so they're off the mark a lot. Analysing the numbers five ways and reporting the way that worked, p-hacking, hands the win to luck. And a dull null goes in a drawer while the shocker gets printed, publication bias, so the shelves are all shockers. Nobody had been doing the redos either, because journals pay for novelty, not for re-treading old ground. Inside the 100 there was a pattern worth keeping: the solid, unglamorous results mostly stood, and the ones that grabbed headlines mostly folded. The team also said what the coverage skipped. A redo that fails isn't proof the original was a false alarm, because redos miss by chance too, or a small change in setup tipped it. It leaves one study looking thin, nothing more. The repairs are unglamorous as well: lock in your number-crunching plan before you collect one data point, sign up more people, have journals approve the blueprint before the results exist, and open up the data. Your move is easy. One study is a rough draft. Wait for the second. 😎

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Analogy

The replication crisis is what a field finds when it reruns its published studies and many do not come out the same, and a first night at bowling shows why one result is not a level. Someone bowls for the first time and scores 180, and the group talks about nothing else. Over the next ten weeks they average 110. The 180 was real: the pins fell. It was also one game, and one game mixes skill with luck, so it was a poor guide to how good the bowler is. Only the repeats showed that. A league that records first games and never the repeats would have a book full of 180s, and its members would look far better than they are. A field that publishes first results and rarely reruns them has that book. The low repeats do not make the 180 a lie, and a failed replication does not make the first study false. The match ends there: a bowler can rerun for the price of a lane, and an experiment can cost years, which is why so few were rerun.
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Analogy

The replication crisis is a field redoing its own published studies and finding many don't hold up, and the internet Wi-Fi fix is the same story in a weekend. A stranger posts that moving the router to the kitchen doubled their speed. 4,000 upvotes. You move yours. Nothing. Hundreds of others try it and the replies fill up with "didn't work for me". The poster wasn't lying. Their speed really did double that day, probably because an update finished or the neighbour's download ended. One lucky try, loudly shared, is how the tip got famous, and the crowd trying it is the replication. Science's version ran the same way, with two differences. The published tip sat unchecked for years before a soul tried it. And the field's habits (tiny tests, trying angles until one works, printing only the wins) meant the shelves held a lot of kitchen routers. Where it breaks: a thread gets its reruns in a weekend. Science waited decades. 😎

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Formal definition β€” The same term, explained the usual way

The replication crisis (also reproducibility or replicability crisis) is the recognition, from roughly 2011 onward, that a substantial proportion of published findings in psychology, medicine, economics and other empirical fields fail to replicate when independent researchers repeat the study with new data. Replication refers to re-running a study's method on new participants; reproducibility refers to re-deriving a result from the original data. The Reproducibility Project: Psychology (Open Science Collaboration, Science 349, aac4716, 2015) replicated 100 studies from three 2008 journal volumes: 97% of originals and 36% of replications reported statistically significant results, replication effect sizes were about half the originals', and 39% were subjectively rated as replicated. Contributing factors include low statistical power, undisclosed analytic flexibility (p-hacking, HARKing), publication bias and a low base rate of true hypotheses. Responses include preregistration, registered reports, larger samples, open data and code, and multi-site replication consortia. A failed replication is not by itself evidence that the original was a false positive.

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